Study BMB 464 Exam 1 Ebola and Marburg Flash Cards

 
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BMB 464 Exam 1 Ebola and Marburg

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GP as antigenic target?
-expression of GP alone sufficient to confer protection to NHP
-no vaccine w/o GP can protect against challenge
-GP induces apoptosis of T cells
-point mutations can reduce cytotoxicity of GP
vaccine development
-complicated by divergence b/w species
-GP proteins from ZEBOV and SEBOV share 50% homology
-no cross-reactivity b/w filoviruses
-immunity against Ebola doesn't protect against Marburg and vice versa
sGP
-non-structural form expressed on EBOV
-shares N term w/ viral GP
-expressed at high level during infection
filoviruses protein vaccine target
-GP protein (only surface protein)
-transmembrane (extracellular and membrane anchored parts)
-forms homotrimers
-sGP
Filoviridae family tree
2 genera: Ebola and Marburg viruses

Ebola virus divided into 4 species:
-SEBOV
-ZEBOV
-ICEBOV
-REBOV

-Marburg single species
-MARV
why is Ebola and Marburg a threat?
-filoviruses can easily aerosolize
-high fatality
-no treatment/prevention
-biowarfare?
outbreak history
1967: Marburg, Germany
-lab workers who handled monkeys

1976: along Ebola River
-very similar to Marburg virus
-2 different strains (Ebola Zaire ZEBOV and Ebola Sudan SEBOV)

-2 additional isolates: Ivory Coast ICEBOV and Reston, VA REBOV)
Ebola and Marburg disease
-incubation 4-10 days
-death usually occurs in 10 days
Ebola and Marburg viruses
-originate in Africa
-normally infect NHP (non-human primates) through air
-cause septic shock, systemic failure
-reservoir in fruit bats?
filoviruses
-enveloped
-non-segmented
-RNA
-filamentous shape
Ebola and Marburg viruses are in the _________ family
Filoviridae
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