Study BMB 401H Chap 15 Flash Cards

 
Pile Management Card
BMB 401H Chap 15

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p-nitrophenolacetate hydrolysis
role of imidizole in H bonding to H-O-H to make it a stronger nucleophile
general acid/base catalyst
-acid or base other than H+ or OH- accelerates reaction
-Acid/base groups on enzyme serve this role. Asp, Glu, His
general base catalysis
partial proton abstraction increases rate of reaction by Bronstead base
catalysts
-process that increases rate of reaction approaching equilibrium
-lowers deltaG++
-stabilizes TS
general acid catalysis
-process where a partial proton transfer from a Bronstead acid lowers the free energy of the TS
Factors that contribute to catalytic power of enzymes
Acid/Base catalysis
Covalent catalysis
Metal ion catalysis
Electrostatic catalysis
Proximity and orientation
Preferential binding of the transition state
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