Study BMB 401H Chap 15 Flash Cards
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Pile Management Card
BMB 401H Chap 15
BMB 401H Chap 15
| p-nitrophenolacetate hydrolysis |
| role of imidizole in H bonding to H-O-H to make it a stronger nucleophile |
| general acid/base catalyst |
|
-acid or base other than H+ or OH- accelerates reaction -Acid/base groups on enzyme serve this role. Asp, Glu, His |
| general base catalysis |
| partial proton abstraction increases rate of reaction by Bronstead base |
| catalysts |
|
-process that increases rate of reaction approaching equilibrium -lowers deltaG++ -stabilizes TS |
| general acid catalysis |
| -process where a partial proton transfer from a Bronstead acid lowers the free energy of the TS |
| Factors that contribute to catalytic power of enzymes |
|
Acid/Base catalysis Covalent catalysis Metal ion catalysis Electrostatic catalysis Proximity and orientation Preferential binding of the transition state |
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