Study BMB 400 Chapter 14 New Shiz Flash Cards

 
Pile Management Card
BMB 400 Chapter 14 New Shiz

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guide RNA
-in 20S RNP
-editosome
inosine
-deaminated adenosine
-pairs w/ C
ADAR
converts adenosine to inosine
cytidine deaminase
-demaninates C to U
cycloheximide
-euk
-inhibits P site
puromycin
-pro and euk
-chain terminator
-acts as acceptor for nascent polypeptide chain
-leaves w/ unfinished protein
Chloramphenicol
-pro
-blocks correct positioning of A site for peptidyl transfer rxn
-blocks 'kinkiness'
tetracycline
-pro
-target A site
-inhibits A site
EF-Ts
-GTP exchange factor for EF-Tu
dihydrouridine
-reducetion of double bond in uridine
sigma
pseudodouridine
-5'C replaced by 5'N
euk initiation
-regulated globally by eIF4E binding proteins (4E-BPs)
regulation of ribosomal protein exrepssion
-2 proteins are made to bind to tRNA
-if no tRNA around, protein 2 binds to its own mRNA
-stops translation of protein 1
-self-regulating!
ferretin
-iron regulatory element (IRE)
-if no iron, iron regulatory protein (IRP) binds tightly
-no ferritin translated
-when Fe goes up and need for ferretin increases, IRP binds to Fe and translation occurs of ferritin protein
Gcn4
-biosynthesis of aa's
-if starving, less Met around to start synthesis
-Gcn4 present when starving to make aa's
stalled ribosomes (in pro)
-if no stop codon
-gets to very end of mRNA
-in pro, tmRNA called SsrA
-comes w/ EF-Tu GDP and everything
-adds tag to incomplete protein for degradation
euk mRNA w/ no stop codon
-poly-A tail translated
-Ski7 exosome degrades mRNA
-poly-lys at end of protein rapidly degraded
euk mRNA w/ premature (nonsense) stop codon
-decapping 5' enzyme
-5' cap removed
-rapidly degraded
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