Study BMB 400 Chapter 14 Regulation Flash Cards

 
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BMB 400 Chapter 14 Regulation

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Eukaryotic mRNAs with premature or no stop codons
are targeted for degradation
SsrA
-tmRNA
-rescues stalled ribosomes on prematurely terminated mRNA
stalled translation complex
-formed if no stop codon
-pro: stalled ribosomes rescued by tmRNA (part tRNA, part mRNA)
-Releases stalled ribosome
-Tag added to incomplete protein for degradation
ferritin translation regulation
-influenced by [] of iron in cells and iron-binding proteins (IRPs).
eIF4E-binidng protein (4E-BPs)
-globally regulate euk translation initiation
Translation detects defective mRNAs...
...and eliminates either mRNA or their protein products
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