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| GP as antigenic target? |
-expression of GP alone sufficient to confer protection to NHP
-no vaccine w/o GP can protect against challenge
-GP induces apoptosis of T cells
-point mutations can reduce cytotoxicity of GP |
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mcs5109 Mon, 28 Sep 2009 03:46:22 GMT |
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| vaccine development |
-complicated by divergence b/w species
-GP proteins from ZEBOV and SEBOV share 50% homology
-no cross-reactivity b/w filoviruses
-immunity against Ebola doesn't protect against Marburg and vice versa |
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mcs5109 Mon, 28 Sep 2009 03:46:22 GMT |
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| sGP |
-non-structural form expressed on EBOV
-shares N term w/ viral GP
-expressed at high level during infection |
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mcs5109 Mon, 28 Sep 2009 03:46:22 GMT |
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| filoviruses protein vaccine target |
-GP protein (only surface protein)
-transmembrane (extracellular and membrane anchored parts)
-forms homotrimers
-sGP |
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mcs5109 Mon, 28 Sep 2009 03:46:22 GMT |
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| Filoviridae family tree |
2 genera: Ebola and Marburg viruses
Ebola virus divided into 4 species:
-SEBOV
-ZEBOV
-ICEBOV
-REBOV
-Marburg single species
-MARV |
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mcs5109 Mon, 28 Sep 2009 03:40:07 GMT |
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| why is Ebola and Marburg a threat? |
-filoviruses can easily aerosolize
-high fatality
-no treatment/prevention
-biowarfare? |
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mcs5109 Mon, 28 Sep 2009 03:40:07 GMT |
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| outbreak history |
1967: Marburg, Germany
-lab workers who handled monkeys
1976: along Ebola River
-very similar to Marburg virus
-2 different strains (Ebola Zaire ZEBOV and Ebola Sudan SEBOV)
-2 additional isolates: Ivory Coast ICEBOV and Reston, VA REBOV) |
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mcs5109 Mon, 28 Sep 2009 03:40:07 GMT |
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| Ebola and Marburg disease |
-incubation 4-10 days
-death usually occurs in 10 days |
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mcs5109 Mon, 28 Sep 2009 03:30:29 GMT |
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| Ebola and Marburg viruses |
-originate in Africa
-normally infect NHP (non-human primates) through air
-cause septic shock, systemic failure
-reservoir in fruit bats? |
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mcs5109 Mon, 28 Sep 2009 03:30:29 GMT |
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| filoviruses |
-enveloped
-non-segmented
-RNA
-filamentous shape |
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mcs5109 Mon, 28 Sep 2009 03:30:28 GMT |
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| Ebola and Marburg viruses are in the _________ family |
Filoviridae |
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mcs5109 Mon, 28 Sep 2009 03:30:28 GMT |
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