| front |
back |
revisions |
lasted changed by |
history |
| standard genetic code |
-widespread but not universal
-ex: RNA derived from mito DNA |
0 |
mcs5109 Fri, 24 Oct 2008 04:40:44 GMT |
 |
| genetic interaction |
-product of mutated gene interacts with the original product
-2 genes don't physically interact |
0 |
mcs5109 Fri, 24 Oct 2008 04:40:44 GMT |
|
| supressing frameshift mutations |
-if deletion occurs, add a nucleotide!
-aka suppressor of frameshift mutation
-can be different codon or different gene! |
0 |
mcs5109 Fri, 24 Oct 2008 04:40:44 GMT |
|
| frameshift |
-insertion/deletion that changes reading frame |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| nonsense |
-cause abrupt termination |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| missense |
-replacement of 1 aa |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| nonsilent |
-do change aa
-non-degenerate positions
-likely subject to evolutionary selection |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| silent mutation |
-does not change aa
-occur in degenerate positions
-most frequent b/c don't really matter
-used for adjusting GC% of genomes |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| pairings |
G: U or C
C: G
A: U
U: A or G
I: A, U, or G |
0 |
mcs5109 Fri, 24 Oct 2008 04:27:22 GMT |
|
| inosine |
deamination of adenosine
-enzymatic rxn |
0 |
mcs5109 Fri, 24 Oct 2008 04:22:15 GMT |
|
| 61 codons can be read by ___ tRNAs |
evidence: higly purifed tRNAs could recognize >1 codon |
0 |
mcs5109 Fri, 24 Oct 2008 04:22:15 GMT |
|
| wobble base |
-last codon (of 3' end)
-first anticodon (of 5' end) |
0 |
mcs5109 Fri, 24 Oct 2008 04:22:15 GMT |
|
| are all codons used euqally? |
Hellz to the NO!
-pattern of usage corresponds to species/tissues |
0 |
mcs5109 Fri, 24 Oct 2008 04:22:15 GMT |
|
| purine in the 2nd position |
-usually hydrophilic aa's |
0 |
mcs5109 Fri, 24 Oct 2008 04:18:28 GMT |
|
| pyrimidine in 2nd position |
-usually hydrophobic aa's |
0 |
mcs5109 Fri, 24 Oct 2008 04:18:28 GMT |
|
| change 1st codon... |
...will give you a similar aa |
0 |
mcs5109 Fri, 24 Oct 2008 04:18:28 GMT |
|
| degeneracy |
-almost all aa's are encoded by multiple codons
-found primarily in 3rd position |
0 |
mcs5109 Fri, 24 Oct 2008 04:18:28 GMT |
|
