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| guide RNA |
-in 20S RNP
-editosome |
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mcs5109 Fri, 24 Oct 2008 06:11:18 GMT |
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| inosine |
-deaminated adenosine
-pairs w/ C |
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mcs5109 Fri, 24 Oct 2008 06:11:18 GMT |
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| ADAR |
converts adenosine to inosine |
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mcs5109 Fri, 24 Oct 2008 06:11:18 GMT |
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| cytidine deaminase |
-demaninates C to U |
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mcs5109 Fri, 24 Oct 2008 06:11:18 GMT |
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| cycloheximide |
-euk
-inhibits P site |
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mcs5109 Fri, 24 Oct 2008 04:07:11 GMT |
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| puromycin |
-pro and euk
-chain terminator
-acts as acceptor for nascent polypeptide chain
-leaves w/ unfinished protein |
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mcs5109 Fri, 24 Oct 2008 04:07:10 GMT |
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| Chloramphenicol |
-pro
-blocks correct positioning of A site for peptidyl transfer rxn
-blocks 'kinkiness' |
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mcs5109 Fri, 24 Oct 2008 04:07:10 GMT |
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| tetracycline |
-pro
-target A site
-inhibits A site |
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mcs5109 Fri, 24 Oct 2008 04:07:10 GMT |
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| EF-Ts |
-GTP exchange factor for EF-Tu |
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mcs5109 Fri, 24 Oct 2008 04:03:44 GMT |
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| dihydrouridine |
-reducetion of double bond in uridine |
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mcs5109 Fri, 24 Oct 2008 04:03:44 GMT |
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| sigma |
pseudodouridine
-5'C replaced by 5'N |
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mcs5109 Fri, 24 Oct 2008 04:03:44 GMT |
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| euk initiation |
-regulated globally by eIF4E binding proteins (4E-BPs) |
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mcs5109 Fri, 24 Oct 2008 02:53:20 GMT |
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| regulation of ribosomal protein exrepssion |
-2 proteins are made to bind to tRNA
-if no tRNA around, protein 2 binds to its own mRNA
-stops translation of protein 1
-self-regulating! |
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mcs5109 Fri, 24 Oct 2008 02:53:20 GMT |
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| ferretin |
-iron regulatory element (IRE)
-if no iron, iron regulatory protein (IRP) binds tightly
-no ferritin translated
-when Fe goes up and need for ferretin increases, IRP binds to Fe and translation occurs of ferritin protein |
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mcs5109 Fri, 24 Oct 2008 02:45:49 GMT |
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| Gcn4 |
-biosynthesis of aa's
-if starving, less Met around to start synthesis
-Gcn4 present when starving to make aa's |
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mcs5109 Fri, 24 Oct 2008 02:41:39 GMT |
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| stalled ribosomes (in pro) |
-if no stop codon
-gets to very end of mRNA
-in pro, tmRNA called SsrA
-comes w/ EF-Tu GDP and everything
-adds tag to incomplete protein for degradation |
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mcs5109 Fri, 24 Oct 2008 02:38:05 GMT |
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| euk mRNA w/ no stop codon |
-poly-A tail translated
-Ski7 exosome degrades mRNA
-poly-lys at end of protein rapidly degraded |
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mcs5109 Fri, 24 Oct 2008 02:38:05 GMT |
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| euk mRNA w/ premature (nonsense) stop codon |
-decapping 5' enzyme
-5' cap removed
-rapidly degraded |
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mcs5109 Fri, 24 Oct 2008 02:38:05 GMT |
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