PSYC 220 Exam #1 Flash Cards

 
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Antagonist

Endogenous Opioids
Naltrexone 0 celesteallen Sat, 06 Feb 2010 20:45:12 GMT view revision history
Agonist

Endogenous Opioids
Morphine 0 celesteallen Sat, 06 Feb 2010 20:45:12 GMT view revision history
Antagonist

GABA
Ro 15-4513 0 celesteallen Sat, 06 Feb 2010 20:45:12 GMT view revision history
Agonist

GABA
Barbiturates 0 celesteallen Sat, 06 Feb 2010 20:44:13 GMT view revision history
Agonist

GABA
Alcohol 0 celesteallen Sat, 06 Feb 2010 20:44:13 GMT view revision history
Antagonist

Glutamate
Ketamine 0 celesteallen Sat, 06 Feb 2010 20:44:13 GMT view revision history
Antagonist

Glutamate
PCP 0 celesteallen Sat, 06 Feb 2010 20:44:13 GMT view revision history
Agonist

Norepinephrine
SNRIs 0 celesteallen Sat, 06 Feb 2010 20:43:30 GMT view revision history
Agonist

Norepinephrine
Strattera 0 celesteallen Sat, 06 Feb 2010 20:43:30 GMT view revision history
Agonist

Dopamine
Amphetamine 0 celesteallen Sat, 06 Feb 2010 20:43:30 GMT view revision history
Agonist

Dopamine
Cocaine 0 celesteallen Sat, 06 Feb 2010 20:43:30 GMT view revision history
Antagonist(s)

Dopamine
Typical OR Atypical Antipsychotics 0 celesteallen Sat, 06 Feb 2010 20:42:35 GMT view revision history
Antagonist

Serotonin
Ondansetron 0 celesteallen Sat, 06 Feb 2010 20:42:35 GMT view revision history
Agonist

Serotonin
Fluoxetine 0 celesteallen Sat, 06 Feb 2010 20:42:35 GMT view revision history
Agonist

Acetylcholine
Muscarine 0 celesteallen Sat, 06 Feb 2010 20:42:35 GMT view revision history
Antagonist

Acetylcholine
Curare 0 celesteallen Sat, 06 Feb 2010 20:41:11 GMT view revision history
Agonist

Acetylcholine
Nicotine 0 celesteallen Sat, 06 Feb 2010 20:41:11 GMT view revision history
Muscarine (agonist) 3rd ant/ag for Acetylcholine 0 celesteallen Sat, 06 Feb 2010 20:41:11 GMT view revision history
Curare (antagonist) 2nd ant/ag for Acetylcholine 0 celesteallen Sat, 06 Feb 2010 20:41:11 GMT view revision history
Nicotine (agonist) 1st ant/ag for Acetylcholine 0 celesteallen Sat, 06 Feb 2010 20:39:44 GMT view revision history
Activates muscle
Arousal
Attention
3) behavioral effects of Acetylcholine (Ach) 0 celesteallen Sat, 06 Feb 2010 20:39:44 GMT view revision history
1. Muscarinic
2. Nicotinic
2) receptors for Acetylcholine (Ach) 0 celesteallen Sat, 06 Feb 2010 20:39:44 GMT view revision history
Naltrexone (antagonist) 2nd ant/ag of Endogenous Opioids 0 celesteallen Sat, 06 Feb 2010 20:39:44 GMT view revision history
Morphine (agonist) 1st ant/ag for Endegenous Opioids 0 celesteallen Sat, 06 Feb 2010 20:36:48 GMT view revision history
Sexual behaviors
Analgesia
Respiration
3) behavioral effects of Endegenous Opioids 0 celesteallen Sat, 06 Feb 2010 20:36:48 GMT view revision history
1. Mu
2. Kappa
3. Delta
3) receptors for Endegenous Opioids 0 celesteallen Sat, 06 Feb 2010 20:36:48 GMT view revision history
1. Endorphins
2. Enkephalins
3. Dynorphins
3) types of Endegenous Opioids 0 celesteallen Sat, 06 Feb 2010 20:36:48 GMT view revision history
Ro 15-4513 (antagonist) 3rd ant/ag of GABA 0 celesteallen Sat, 06 Feb 2010 20:35:10 GMT view revision history
Barbiturates (agonist) 2nd ant/ag of GABA 0 celesteallen Sat, 06 Feb 2010 20:35:10 GMT view revision history
Alcohol (agonist) 1st ant/ag of GABA 0 celesteallen Sat, 06 Feb 2010 20:35:10 GMT view revision history
Regulate neural excitability
Inhibition
Brain development
3) behavioral effects of GABA 0 celesteallen Sat, 06 Feb 2010 20:35:10 GMT view revision history
1. GABA-A
2. GABA-B
2) receptors for GABA 0 celesteallen Sat, 06 Feb 2010 20:33:46 GMT view revision history
Ketamine (antagonist) 2nd ant/ag for Glutamate 0 celesteallen Sat, 06 Feb 2010 20:33:46 GMT view revision history
PCP (antagonist) 1st ant/ag for Glutamate 0 celesteallen Sat, 06 Feb 2010 20:33:46 GMT view revision history
Synaptic Plasticity
Learning
Memory
3) behavioral effects of Glutamate 0 celesteallen Sat, 06 Feb 2010 20:33:46 GMT view revision history
1. NMDA
2. AMPA
3. mGlu
3) receptors associated with Glutamate 0 celesteallen Sat, 06 Feb 2010 20:31:57 GMT view revision history
SNRIs (agonist) 2nd ant/ag of Norepinephrine 0 celesteallen Sat, 06 Feb 2010 20:31:57 GMT view revision history
Stattera (agonist) 1st ant/ag of Norepinephrine 0 celesteallen Sat, 06 Feb 2010 20:31:57 GMT view revision history
'Fight or flight'
Stress
Arousal
Mood
4) behavioral effects of Norepinephrine 0 celesteallen Sat, 06 Feb 2010 20:31:57 GMT view revision history
Adrenergic Receptors Receptor of Norepinephrine (NE) 0 celesteallen Sat, 06 Feb 2010 20:29:58 GMT view revision history
Amphetamine (agonist) 4th ant/ag of Dopamine 0 celesteallen Sat, 06 Feb 2010 20:29:58 GMT view revision history
Cocaine (agonist) 3rd ant/ag of Dopamine 0 celesteallen Sat, 06 Feb 2010 20:29:58 GMT view revision history
Atypical antipsychotics (antagonist) 2nd ant/ag of Dopamine 0 celesteallen Sat, 06 Feb 2010 20:29:58 GMT view revision history
Typical antipsychotics (antagonist) 1st ant/ag of Dopamine 0 celesteallen Sat, 06 Feb 2010 20:28:38 GMT view revision history
Voluntary movement
Motivation/reward
Drug abuse
Mood
Learning
5) behavioral effects of Dopamine 0 celesteallen Sat, 06 Feb 2010 20:28:38 GMT view revision history
D1-5 Receptor for Dopamine 0 celesteallen Sat, 06 Feb 2010 20:28:38 GMT view revision history
Fluoxetine 3rd ant/ag of Serotonin

agonist
0 celesteallen Sat, 06 Feb 2010 20:28:38 GMT view revision history
Ondansetron (antagonist) 2nd ant/ag of Serotonin

2 celesteallen Mon, 08 Feb 2010 14:52:43 GMT view revision history
SSRIs 1st ant/ag of Serotonin

agonist
0 celesteallen Sat, 06 Feb 2010 20:26:45 GMT view revision history
Mood
Appetite
Social Dominance
Aggression
Behavioral effects of Serotonin 0 celesteallen Sat, 06 Feb 2010 20:26:45 GMT view revision history
5HT1-5 Receptors for Serotonin 0 celesteallen Sat, 06 Feb 2010 20:26:45 GMT view revision history
Autism Disorder caused by abnormal course of social development

Lack of social cognition

Deficient in theory of mind (?)

Associated brain regions: OFC, medial temporal love, abnormal development of neuronal connections, lack of programmed cell death
0 celesteallen Thu, 04 Feb 2010 18:11:04 GMT view revision history
Representations / Object permanence Developmental milestone

Involves prefrontal cortex

Understanding an object is still present although can't see it

Developed by age 10
0 celesteallen Thu, 04 Feb 2010 18:11:04 GMT view revision history
Facial Recognition Developmental milestone

Involves visual cortex and sub-cortical regions

Infants develop this ability
0 celesteallen Thu, 04 Feb 2010 18:11:04 GMT view revision history
Complete Androgen Insensitivity Syndrome (CAIS) Heading: 'environment and human sexual development'

XY genotype (sex: male)

Produce testosterone normally, but lack androgen receptors

Feminization of genitals

Female-biased play behaviors; identify as female

No male-biased behavior
0 celesteallen Thu, 04 Feb 2010 18:03:18 GMT view revision history
Congenital Adrenal Hyperplasia (CAH) Heading: 'atypical hormonal effects'

Females exposed to high levels of testosterone in the womb

Masculinizing of genitals

Male-biased play behavior; career

Higher rates of homosexuality among this population
1 celesteallen Mon, 08 Feb 2010 14:30:03 GMT view revision history
Puberty Heading: 'environment and human sexual development'

When sex hormones stimulate further sex differentiation (ie, sexual characteristics)
0 celesteallen Thu, 04 Feb 2010 18:01:18 GMT view revision history
Gender Identity Heading: 'environment and human sexual development'

Development of this occurs ages 2-4 and may further influence sex differentiation of CNS
0 celesteallen Thu, 04 Feb 2010 18:01:18 GMT view revision history
Gender Term used to refer the environment's role in determining expression/label as male or female

- Development of gender-specific roles influenced by both genetics and environment
0 celesteallen Thu, 04 Feb 2010 18:01:18 GMT view revision history
Sex Term referring to the biological characteristics of an individual

- Development of sex-specific characteristics guided by genes and hormones
0 celesteallen Thu, 04 Feb 2010 17:56:56 GMT view revision history
sexually dimorphic nucleus of the preoptic area (SDN-POA) Androgen inhibits cell death of this, which is located in the hypothalamus, resulting in masculinizing effects of the CNS and later, resulting male behaviors later in life 0 celesteallen Thu, 04 Feb 2010 17:56:56 GMT view revision history
"Sexually indifferent stage" The stage in sexual development during which gonads are not fully developed as male / female 0 celesteallen Thu, 04 Feb 2010 17:56:56 GMT view revision history
Organizational Effects Heading: 'Hormones and Development'

Effects of hormones that produce lasting or long-term alterations in structure during development

- Penetrate the membrane and directly alter gene expression--protein--structure of neuron
0 celesteallen Thu, 04 Feb 2010 17:56:56 GMT view revision history
Activational Effects Heading: 'Hormones and Development'

Effects of hormones that produce transient actions at target cells by occupying receptors
0 celesteallen Thu, 04 Feb 2010 17:44:44 GMT view revision history
Renervation Process called when preganglionic connection in 1 and postganglionic connection in 2 is restored 0 celesteallen Thu, 04 Feb 2010 17:44:44 GMT view revision history
Sprouting Process called when new neurons form new connections to restore a nerve that has undergone denervation

(new neurons formed at 1 and 3)
0 celesteallen Thu, 04 Feb 2010 17:44:44 GMT view revision history
Denervation Loss of a neural connection 0 celesteallen Thu, 04 Feb 2010 17:44:44 GMT view revision history
Programmed Cell Death (PCD) OR Apoptosis Term that refers to when cells spontaneously kills themselves 0 celesteallen Tue, 02 Feb 2010 18:40:51 GMT view revision history
Neurotropic Factors Cells able to take up these factors are able to preserve necessary synapses

Secreted by target cells

Ex: nerve growth factor
0 celesteallen Tue, 02 Feb 2010 18:40:51 GMT view revision history
Chemoattraction Specific part of neuron (axon) is attracted to the target cell, which is releasing guidepost cells

General Definition: Attraction of part of a growing cell towards chemical cues in its environment
0 celesteallen Tue, 02 Feb 2010 18:37:00 GMT view revision history
Denervation Loss of neural supply; interruption of nerve connection to an organ or part 0 celesteallen Tue, 02 Feb 2010 18:27:50 GMT view revision history
Synaptic Restructuring Stage 6 of Development (LAST stage)

j) behavior helps maintain and strengthen certain synapses and weed out others

- synaptic restructuring is ongoing throughout life
- synaptic transmission strengthens synapses
- lack of communication weakens synapses
- repair after trauma
0 celesteallen Tue, 02 Feb 2010 18:27:50 GMT view revision history
Apoptosis AKA: programmed cell death

Provoked by expression of 'suicide genes'

Typically confers advantages during an organism's life cycle
EX: attributed to the differentiation of fingers and toes in a developing human embryo
0 celesteallen Tue, 02 Feb 2010 18:27:50 GMT view revision history
Synaptogenesis and Selective Cell Death Stages 4 & 5 of Development

h) neurites of proximal cells form synapses
*neurotropic factors secreted by target cells create and preserve necessary synapses

i) synaptic connections are strengthened or removed
0 celesteallen Tue, 02 Feb 2010 18:19:57 GMT view revision history
Differentiation Stage 3 of Development

f) distinct cell types develop distinct shapes

g) ...and structures
0 celesteallen Tue, 02 Feb 2010 18:19:57 GMT view revision history
Migration Stage 2 of Development

d) special chemicals attract specific cells

e) using these chemicals as guides, cells are directed towards their appropriate place in the CNS
0 celesteallen Tue, 02 Feb 2010 18:19:57 GMT view revision history
Neurogenesis Stage 1 of Development

a) precursor cells give rise to neurons at the neural tube

b) cells repeatedly divide

c) cell division stops
0 celesteallen Tue, 02 Feb 2010 18:19:57 GMT view revision history
Synaptic Reorganization Heading: "Stages of Development"

Synapses are strengthened / weakened

SIXTH stage of development (of 6)
0 celesteallen Tue, 02 Feb 2010 18:10:45 GMT view revision history
Selective neuron death Heading: "Stages of Development"

Some neurons are destroyed / die off

FIFTH stage of development (of 6)
0 celesteallen Tue, 02 Feb 2010 18:10:45 GMT view revision history
Synaptogenesis Heading: "Stages of Development"

Synapses begin to form between neurons

FOURTH stage of development (of 6)
0 celesteallen Tue, 02 Feb 2010 18:10:45 GMT view revision history
Differentiation Heading: "Stages of Development"

Types of neurons arise from a standard precursor neuron; neurites begin to form from neurons

THIRD stage of development (of 6)
0 celesteallen Tue, 02 Feb 2010 18:10:45 GMT view revision history
Migration Heading: "Stages of Development"

Neurons move towards their final anatomical location

SECOND stage of development
0 celesteallen Tue, 02 Feb 2010 18:08:36 GMT view revision history
Neurogenesis Heading: "Stages of Development"

Cells of the neural tube repeatedly divide

FIRST stage of development
0 celesteallen Tue, 02 Feb 2010 18:08:36 GMT view revision history
Neural Tube Heading: "Development of the CNS"

Made up by:
-stem cells

-caudal portion

-rostral portion

-cavity
0 celesteallen Tue, 02 Feb 2010 18:08:36 GMT view revision history
Neural Crest Develops into PNS 0 celesteallen Tue, 02 Feb 2010 18:08:36 GMT view revision history
Cavity Heading: "Development of the CNS"

Part of neural tube

Forms---ventricles and central canal of spinal cord
0 celesteallen Tue, 02 Feb 2010 18:03:33 GMT view revision history
Rostral portion Heading: "Development of the CNS"

Part of neural tube

Forms---brain
0 celesteallen Tue, 02 Feb 2010 18:03:33 GMT view revision history
Caudal portion Heading: "Development of the CNS"

Part of neural tube

Forms---spinal cord
0 celesteallen Tue, 02 Feb 2010 18:03:33 GMT view revision history
Stem cells Heading: "Development of the CNS"

Part of neural tube

Forms---neurons and glial cells
0 celesteallen Tue, 02 Feb 2010 18:03:33 GMT view revision history
Dizygotic Twins Twins tat are fraternal 0 celesteallen Tue, 02 Feb 2010 18:00:10 GMT view revision history
Monozygotic Twins Twins that are identical 0 celesteallen Tue, 02 Feb 2010 18:00:10 GMT view revision history
Learning Heading: "development v learning"

Experience-dependent

Largely shaped by environment

Generally reversible
0 celesteallen Tue, 02 Feb 2010 18:00:10 GMT view revision history
Development Heading: "development v learning"

Time-dependent

Involves environment

Generally irreversible
0 celesteallen Tue, 02 Feb 2010 18:00:10 GMT view revision history
Single-unit recording Stereotaxic surgery to place recording microelectrodes in specific brain regions to record from a single neuron

-Record activity / inhibition of a single neuron's activity during behaviors
0 celesteallen Tue, 02 Feb 2010 17:57:30 GMT view revision history
Experimental lesions / ablations Heading: "Learning from brain damage"

Targeted brain regions are strategically damaged and resulting behavioral deficits are observed

Stereotaxic surgery
0 celesteallen Tue, 02 Feb 2010 17:57:30 GMT view revision history
Loss of funtion Heading: "Learning from brain damage"

Localized site of damage correlates with specific behavioral deficits
0 celesteallen Tue, 02 Feb 2010 17:57:30 GMT view revision history
Microdialysis Heading: "Quantifying Neurochemicals"

Uses a special probe to collect fluid samples containing extrasynaptic neurochemicals
0 celesteallen Tue, 02 Feb 2010 17:57:30 GMT view revision history
Functional MRI (fMRI) Heading: "Techniques for Imaging"

Functional AND structural

Measures oxygen consumption in high resolution
0 celesteallen Tue, 02 Feb 2010 17:54:04 GMT view revision history
Theory of Mind A theory that holds that you can infer the intentions of other organism's using sensory information

Facilitated by enlarged Prefrontal cortices (?)
0 celesteallen Tue, 02 Feb 2010 17:54:04 GMT view revision history
Magnetic Resonance Imaging (MRI) Heading: "Techniques for Imaging"

Structural

Magnetic properties of substances in the body are alined within a magnetic field to derive an image
0 celesteallen Tue, 02 Feb 2010 17:49:39 GMT view revision history
Positron Emisson Tomography (PET) Heading: "Techniques for Imaging"

Functional

Radioactive tracer (ie, radioactive oxygen, glucose, NT precursor) used

Measure blood flow (rCBF) or distribution of a specific NT in brain
0 celesteallen Tue, 02 Feb 2010 17:49:39 GMT view revision history
Computerized Tomography (CT) Heading: "Techniques for Imaging"

Structural

Series of X-rays used to derive an image of the brain
0 celesteallen Tue, 02 Feb 2010 17:49:39 GMT view revision history
Electromyogram Heading: "Non-invasive recording of electrical activity"

Electrodes attached to the surface of the body / attached to muscle itself

Record voltage
0 celesteallen Tue, 02 Feb 2010 17:49:39 GMT view revision history
Evoked Potentials Heading: "Non-invasive recording of electrical activity"

Electrodes attached to surface of head

Record changes in voltage associated with stimuli (event related potentials, ERP)
0 celesteallen Tue, 02 Feb 2010 17:46:06 GMT view revision history
Elecroencephalography (EEG) Heading: "Non-invasive recording of electrical activity"

Electrodes attached to surface of head

Record total whole brain voltage
0 celesteallen Tue, 02 Feb 2010 17:46:06 GMT view revision history
Electron microscopy Heading: "Techniques for Visualizing Neurons"

Investigate staining of specific cells under an electron microscope
0 celesteallen Tue, 02 Feb 2010 17:46:06 GMT view revision history
Nissl staining Heading: "Techniques for Visualizing Neurons"

Type of Histology

-examines cell body stain
0 celesteallen Tue, 02 Feb 2010 17:46:06 GMT view revision history
Golgi staining Heading: "Techniques for Visualizing Neurons"

Type of Histology

-examines whole cell stain
0 celesteallen Tue, 02 Feb 2010 17:43:30 GMT view revision history
Histology Heading: "Techniques for Visualizing Neurons"

Investigate staining of specific cells under a high-powered light microscope

-Golgi staining: whole cell stain

-Nissl staining: cell body stain
0 celesteallen Tue, 02 Feb 2010 17:43:30 GMT view revision history
Retrograde Labeling Heading: "Techniques for Visualizing Neurons"

Inject dye at axon terminals, transported THROUGH AXON to CELL BODY
0 celesteallen Tue, 02 Feb 2010 17:43:30 GMT view revision history
Anterograde Labeling Heading: "Techniques for Visualizing Neurons"

Inject dye into cell nucleus, transported FROM CELL BODY to AXON TERMINALS
0 celesteallen Tue, 02 Feb 2010 17:43:30 GMT view revision history
Principle of Proper Mass A Principle that refers to the fact that the amount of neural tissue devoted to a behavioral function corresponds to the amount of information processing required to successfully perform the function 0 celesteallen Tue, 02 Feb 2010 17:40:17 GMT view revision history
Principle of Localization A Principle that refers to the fact that different structures of the brain have different functions 0 celesteallen Tue, 02 Feb 2010 17:40:17 GMT view revision history
Analogous Refers to a feature evolved independently between species, but resulting from same evolutionary (environmental) pressures 0 celesteallen Tue, 02 Feb 2010 17:40:16 GMT view revision history
Homologous Refers to a common evolutionary origin between species 0 celesteallen Tue, 02 Feb 2010 17:40:16 GMT view revision history
Hypothalamus Regulates feeding behavior

Important for homeostasis

Coordinates stress response

Output projections to many brain regions, including those involved in decision-making
0 celesteallen Thu, 28 Jan 2010 18:33:31 GMT view revision history
Nucleus of the Solitary Tract (NTS) Projections from PNS or cranial nerves arrive to NTS

Output projections to other brain regions
-Liver --> neurons of the PNS --> vagus nerve --> NTS --> hypothalamus
0 celesteallen Thu, 28 Jan 2010 18:32:27 GMT view revision history
Astrocyte-endothelial Interactions The close anatomical association between endothelial cells and per vascular astrocytic end feet suggests cooperation between these cell types in forming and maintaining the blood-brain barrier. 0 celesteallen Thu, 28 Jan 2010 18:32:27 GMT view revision history
Blood Brain Barrier Selective barrier formed between blood vessels and neurons of the brain

-Prevents toxins from penetrating the brain through the bloodstream

-Protects against drastic changes in ion concentrations

-Allows entrance of proper nutrients, hormones (special transport mechanisms; selective laxity of this in specific areas that contain neurons which are extremely sensitive to ion concentration and toxins)
0 celesteallen Thu, 28 Jan 2010 18:32:27 GMT view revision history
Cerebral Spinal Fluid (CSF) Produced in the choroid plexus

Fills ventricles, cerebral aqueduct, central canal of the spinal cord

Cushions the brain against trauma
0 celesteallen Thu, 28 Jan 2010 18:32:27 GMT view revision history
Mammillary body Invovled in recognition

(Part of Limbic System)
0 celesteallen Thu, 28 Jan 2010 18:24:17 GMT view revision history
Hippocampus Receives sensory input from cortex

Forms memories, some of which may have emotional components

Outputs to many brain regions, including through fornix to mammillary body

(Part of Limbic System)
0 celesteallen Thu, 28 Jan 2010 18:24:17 GMT view revision history
Amygdala Receives sensory input from cortex

Coordinate/processes emotional response

Outputs to many brain regions for further processing of emotion

(Part of Limbic System)
1 celesteallen Thu, 28 Jan 2010 18:26:17 GMT view revision history
Telencephalon Part of the brain involved with the Limbic System 0 celesteallen Thu, 28 Jan 2010 18:22:28 GMT view revision history
Amygdala, Hippocampus and Mammillary body Three main components of the Limbic System 0 celesteallen Thu, 28 Jan 2010 18:22:28 GMT view revision history
Dorsolateral, medial, orbitofrontal Three major subdivisions of the prefrontal cortex

Why is this important?
0 celesteallen Thu, 28 Jan 2010 18:22:28 GMT view revision history
Executive Functioning Prefrontal cortex responsible for this

Includes planning, decision making, appropriate social behavior, attention
0 celesteallen Thu, 28 Jan 2010 18:20:25 GMT view revision history
Basal Ganglia and Cerebellum Two areas of the brain involved in motor control 0 celesteallen Thu, 28 Jan 2010 18:20:25 GMT view revision history
Cerebellum Receives input from motor cortex

Balance, locomotion, organizes motor action, coordinate decisions about motor action
0 celesteallen Thu, 28 Jan 2010 18:20:25 GMT view revision history
Basal Ganglia Includes: Caudate nucleus, Globus, Pallidus, Putamen

Receives input from motor cortex

Movement control
0 celesteallen Thu, 28 Jan 2010 18:20:25 GMT view revision history
Motor Cortex Cortex

-Precentral gyrus

-Receives sensory input from PNS, sensory input from other areas of the cortex

-Exerts motor control (skeletal muscles)-- cranial nerves, spinal cord, other brain regions
0 celesteallen Thu, 28 Jan 2010 18:18:09 GMT view revision history
Optic Nerve Cranial nerve II

Transmits visual information from the retina to the brain.
0 celesteallen Thu, 28 Jan 2010 18:18:09 GMT view revision history
Lateral Geniculate Nucleus (LGN) Primary processing center for visual information received from the retina of the eye

Found inside the thalamus of the brain
0 celesteallen Thu, 28 Jan 2010 18:18:09 GMT view revision history
Vision "Sensory cortices"

-Cranial Nerve (optic nerve)

-Receptor cells (retina, light responsive)

-Triggers activation of ganglion cells, which form the optic nerve

-Thalamus (lateral geniculate nucleus)

-Visual Cortex
0 celesteallen Thu, 28 Jan 2010 18:18:09 GMT view revision history
Touch "Sensory cortices"

Nerve fiber from PNS --> ascending tract in CNS

-Crosses sides at medulla

-Projects to thalamus (directs information to subregion of somatosensory cortex)
0 celesteallen Thu, 28 Jan 2010 18:14:21 GMT view revision history
Pain "Sensory cortices"

Nerve fiber from PNS --> ascending tract in CNS

-Crosses sides in spinal cord

-Projects to RAS (emotion/arousal)

-Projects to thalamus (directs to a specific part fo the somatosensory cortex)
0 celesteallen Thu, 28 Jan 2010 18:14:21 GMT view revision history
Thalamus -Receives sensory input from sensory systems

-Projections to the cortex

-Specific (ie, directs specific types of sensory info to a specific parts of the cortex)

-Receives information from cortex
0 celesteallen Thu, 28 Jan 2010 18:14:21 GMT view revision history
Ascending Reticular Activating System (RAS) -Sensory input arrives via spinal cord

-Neurons activated by sensory input

-Projections to cortex

-Non-specific (ie, projects all types of sensory info)

-Wakefulness/alertness and sleep
0 celesteallen Thu, 28 Jan 2010 18:14:21 GMT view revision history
Sensory Humunculus Diagram used to illustrate how much of the cortex is attributed to sensory input from a certain part of the body 0 celesteallen Thu, 28 Jan 2010 18:09:29 GMT view revision history
Association Cortices Regions in the cortex where information from primary cortices is integrated (ie, olfactory and visual information) 0 celesteallen Thu, 28 Jan 2010 18:09:29 GMT view revision history
Somatosensory Cortex Cortex controlled by the parietal lobe

Receives sensory information regarding touch
0 celesteallen Thu, 28 Jan 2010 18:09:29 GMT view revision history
Auditory Cortex Cortex controlled by the temporal lobe

Receives auditory information
0 celesteallen Thu, 28 Jan 2010 18:09:29 GMT view revision history
Visual Cortex Cortex in the occipital lobe

Visual information received via optic nerve
0 celesteallen Thu, 28 Jan 2010 18:07:35 GMT view revision history
Gyri Spaces between the folds that make up the cerebral cortex 0 celesteallen Thu, 28 Jan 2010 18:07:35 GMT view revision history
Sulci Folds that make up the cerebral cortex 0 celesteallen Thu, 28 Jan 2010 18:07:35 GMT view revision history
White matter Myelinated axons make up the inner brain 0 celesteallen Thu, 28 Jan 2010 18:07:35 GMT view revision history
Gray matter (cortex) In the cortex

Cell bodies make up the outer brain
0 celesteallen Thu, 28 Jan 2010 18:06:19 GMT view revision history
Lateral Sulcus A fold in the cerebral cortex of brains in vertebrates

Divides the frontal lobe and parietal lobe above from the temporal lobe below.
0 celesteallen Thu, 28 Jan 2010 18:06:19 GMT view revision history
Central Sulcus A fold in the cerebral cortex of brains in vertebrates also called the central fissure

Separates the parietal lobe from the frontal lobe (and the primary motor cortex from the primary somatosensory cortex)
0 celesteallen Thu, 28 Jan 2010 18:06:19 GMT view revision history
Occipital Lobe Lobe of the brain

Involved in vision
0 celesteallen Thu, 28 Jan 2010 18:06:19 GMT view revision history
Temporal Lobe Lobe of the brain

Involved in hearing/audition and memory
0 celesteallen Thu, 28 Jan 2010 18:03:21 GMT view revision history
Parietal Lobe Lobe of the brain

Involved in sensory information related to touch, pain, temperature
0 celesteallen Thu, 28 Jan 2010 18:03:21 GMT view revision history
Frontal Lobe Lobe of the brain

Involved in decision making, planning, movement, speech and emotion
0 celesteallen Thu, 28 Jan 2010 18:03:21 GMT view revision history
Anterior Commisure Axons of neurons connecting the anterior portions of the two hemispheres 0 celesteallen Thu, 28 Jan 2010 18:03:21 GMT view revision history
Corpus Callosum Axons of neurons connecting the two hemispheres 0 celesteallen Thu, 28 Jan 2010 18:01:41 GMT view revision history
Brain stem "General categorization of the brain"

Made up of the midbrain, pons, medulla
0 celesteallen Thu, 28 Jan 2010 18:01:41 GMT view revision history
Mesencephalon "General categorization of the brain"

Made up of the diencephalon
-Includes the thalamus and hypothalamus

Made up of the midbrain
0 celesteallen Thu, 28 Jan 2010 18:01:41 GMT view revision history
Telencephalon "General categorization of the brain"

Part of brain known as the Cerebrum

Includes the cerebral cortex
0 celesteallen Thu, 28 Jan 2010 18:01:41 GMT view revision history
Horizontal Cut of brain that splits lips half (one lip on top, one on bottom) 0 celesteallen Thu, 28 Jan 2010 17:59:25 GMT view revision history
Coronal Cut of brain that splits the ears in half 0 celesteallen Thu, 28 Jan 2010 17:59:25 GMT view revision history
Sagittal Cut of brain that splits the nose in half 1 celesteallen Tue, 09 Feb 2010 01:10:21 GMT view revision history
Contralateral An anatomical term referring to the opposite side 0 celesteallen Thu, 28 Jan 2010 17:57:50 GMT view revision history
Anterior Another anatomical term for VENTRAL

Refers to...
0 celesteallen Thu, 28 Jan 2010 17:57:50 GMT view revision history
Posterior Another anatomical term for DORSAL

Refers to the back or behind
0 celesteallen Thu, 28 Jan 2010 17:57:50 GMT view revision history
Rostral Another anatomical term for SUPERIOR

Refers to above or on top of
0 celesteallen Thu, 28 Jan 2010 17:57:50 GMT view revision history
Caudal Another anatomical term for inferior 0 celesteallen Thu, 28 Jan 2010 17:53:43 GMT view revision history
Ipsilateral An anatomical term pertaining to the same side 0 celesteallen Thu, 28 Jan 2010 17:53:43 GMT view revision history
Lateral An anatomical term pertaining to the side of the body or a body part that is farther from the middle or center of the body.

Typically refers to the outer side of the body part, but it is also used to refer to the side of a body part.
0 celesteallen Thu, 28 Jan 2010 17:53:43 GMT view revision history
Medial An anatomical term pertaining to the middle; in or toward the middle; nearer the middle of the body.

Within a multi-layered structure, the center layer.
0 celesteallen Thu, 28 Jan 2010 17:53:43 GMT view revision history
Inferior A term pertaining to below or beneath 0 celesteallen Thu, 28 Jan 2010 17:49:23 GMT view revision history
Superior A term pertaining to on top of or above.

Example in the body: relationship of the HEART to the stomach
0 celesteallen Thu, 28 Jan 2010 17:49:23 GMT view revision history
Ventral A term pertaining to the front or anterior of any structure.

Some examples on the body: chest, abdomen, shins, palms, and soles
0 celesteallen Thu, 28 Jan 2010 17:49:23 GMT view revision history
Dorsal A term relating to the back of a structure.

Some examples on the body: Back, butt, calves, knuckles side of the hand
0 celesteallen Thu, 28 Jan 2010 17:49:23 GMT view revision history
Compensatory Mechanisms Under heading: "Homeostatic Regulation of Altered Synapses"

Up-regulation / Down-regulation of synapses / receptors in response to taking drugs of abuse

Term sometimes used to refer to any such changes used to reinstate homeostasis
1 celesteallen Tue, 09 Feb 2010 01:21:53 GMT view revision history
Up-regulation Under heading: "Homeostatic Regulation of Altered Synapses"

-Loss of excitement of a synapse

-# of postsynaptic receptors INCREASED
0 celesteallen Thu, 28 Jan 2010 17:44:40 GMT view revision history
Down-regulation Under heading: "Homeostatic Regulation of Altered Synapses"

-Repeated excitement of a synapse

-# of postsynaptic receptors REDUCED
0 celesteallen Thu, 28 Jan 2010 17:44:40 GMT view revision history
Ionotropic receptor Type of receptor

When neurotransmitters bind to it, it results in the operation of ion channels

Able to DIRECTLY open ion channels, which generates activity in the postsynaptic cell
0 celesteallen Thu, 28 Jan 2010 17:40:52 GMT view revision history
Hemicholinium-3 Drug that impairs spatial learning by depleting ACh

Acts as a direct antagonist

Impairs performance on Morris Water Maze task
0 celesteallen Tue, 26 Jan 2010 18:33:05 GMT view revision history
3. # of postsynaptic receptors Heading: "alterations at synapses": "natural causes"

ONE (3 of 3) example of individual differences at synapses due to genes / environment
0 celesteallen Tue, 26 Jan 2010 18:26:49 GMT view revision history
2. amt of NT properly stored Heading: "alterations at synapses": "natural causes"

ONE (2 of 3) example of individual differences at synapses due to genes / environment
0 celesteallen Tue, 26 Jan 2010 18:26:48 GMT view revision history
1. amt of NT synthesized Heading: "alterations at synapses": "natural causes"

ONE (1 of 3) example of individual differences at synapses due to genes / environment
0 celesteallen Tue, 26 Jan 2010 18:26:48 GMT view revision history
4. Removal from the synapse 4th step in Neurotransmission 0 celesteallen Tue, 26 Jan 2010 18:26:48 GMT view revision history
3. Binding to receptors on postsynaptic neuron 3rd step in Neurotransmission 0 celesteallen Tue, 26 Jan 2010 18:24:24 GMT view revision history
2. Movement across synaptic cleft 2nd step in Neurotransmission 0 celesteallen Tue, 26 Jan 2010 18:24:24 GMT view revision history
1. Release from presynaptic neuron 1st step in Neurotransmission 0 celesteallen Tue, 26 Jan 2010 18:24:24 GMT view revision history
Electircal Synapse Type of synapse

-Neurons touch directly (NO SYNAPSE)

-Electircal events in one neuron induce electrical events in the other neuron
0 celesteallen Tue, 26 Jan 2010 18:24:24 GMT view revision history
Autoreceptors Heading: "Controlling the synapse"

Act as a sensor

Type of receptor typically on presynaptic cell

Serves as part of a feedback mechanism (or loop) in signal transduction

Inhibits release of various (specific) NTs
0 celesteallen Tue, 26 Jan 2010 18:17:42 GMT view revision history
Maintaining sustained activity at receptors Heading: "Controlling the synapse"

Dynamics between presynaptic and postsynaptic neuron

Equal rate of release / rate of breakdown of NT (constantly replacing NT lost)
0 celesteallen Tue, 26 Jan 2010 18:17:42 GMT view revision history
Inactivation Heading: "Controlling the synapse"

Enzyme breaks down NT

Reuptake brings excess NT back into the presynaptic cell
0 celesteallen Tue, 26 Jan 2010 18:14:23 GMT view revision history
Axon Hillock Tapering region between a neurons cell body and its axon

Responsible for summating the graded inputs from the dendrites and producing action potentials if the threshold is reached
0 celesteallen Tue, 26 Jan 2010 18:14:23 GMT view revision history
Net Summation Independent input at axon hillock AND

Simultaneous, integrated input at axon hillock
0 celesteallen Tue, 26 Jan 2010 18:14:23 GMT view revision history
Net Summation Refers to: Once the membrane potential is changed enough at the axon hillock to reach threshold, 0 celesteallen Tue, 26 Jan 2010 18:14:23 GMT view revision history
MAOIs Undesired effects of this drug include

Block enzyme essential for the digestion of certain foods
0 celesteallen Tue, 26 Jan 2010 18:07:29 GMT view revision history
Prozac Undesired effects of this drug include

Block serotonin receptor subtype (5HT2C)

Increases appetite
0 celesteallen Tue, 26 Jan 2010 18:07:29 GMT view revision history
Clominaprine Undesired effects of this drug metabolite include

Block reuptake of norepinephrine

Effects sexual functioning among other behaviors
0 celesteallen Tue, 26 Jan 2010 18:07:29 GMT view revision history
Clomipramine Type of drug intended to block reuptake of serotonin

Treat OCD
0 celesteallen Tue, 26 Jan 2010 18:07:29 GMT view revision history
Blocks reuptake of serotonin to treat OCD What is the desired effect of Clomipramine? 0 celesteallen Tue, 26 Jan 2010 18:04:51 GMT view revision history
Effects One (of 3) way a drug can cause side-effects

Refers to the fact that a drug can alter normal function of target
0 celesteallen Tue, 26 Jan 2010 18:04:51 GMT view revision history
Metabolites One (of 3) way a drug can cause side-effects

Refers to the fact that a drug (or part of the drug...) can alter normal functino of other NTs
0 celesteallen Tue, 26 Jan 2010 18:04:51 GMT view revision history
Specificity One (of 3) way a drug can cause side-effects

Refers to the fact that a drug can alter other mechanisms of the NT system
0 celesteallen Tue, 26 Jan 2010 18:04:51 GMT view revision history
Axon Hillock The anatomical part of a neuron that connects the cell body (soma) to the axon

The location where the summation of IPSPs and EPSPs from numerous synaptic inputs on the dendrites or cell body occurs
0 celesteallen Tue, 26 Jan 2010 18:01:16 GMT view revision history
Dale's Principle The principle stating that a neuron does the same thing at all of its synaptic connections to other cells, regardless of the identity of the target cell.

Has been taken to refer to the fact that:

-neurons release one and only one transmitter at all of their synapses OR
-neurons release the same set of transmitters at all of their synapses.
0 celesteallen Tue, 26 Jan 2010 18:01:16 GMT view revision history
Colocalization Part of Dale's principle

Refers to the fact that different NTs can be released from the same axon terminal?????????
0 celesteallen Tue, 26 Jan 2010 18:01:16 GMT view revision history
MAOIs Type of medicine

-Inhibits the enzyme which breaks down monamine NTs (dopamine, serotonin, epinephrine, norepinephrine)

-Monoamine oxidase inhibitor

-Treatment of depression
0 celesteallen Tue, 26 Jan 2010 18:01:16 GMT view revision history
Prozac (fluoxetine) type of medicine

-Inhibits serotonin reuptake

-Selective serotonin reuptake inhibitor (SSRI)

-Treatment of OCD, depression
0 celesteallen Tue, 26 Jan 2010 17:54:39 GMT view revision history
Compensatory Mechanisms Heading: "Homeostatic regulation of altered synapses"

Evident in withdrawal from drugs of abuse / medication

Ex: cocaine withdrawal--> down-regulatino of DA release without drug --> withdrawal symptoms (dysphoria, anxiety, depression, increased appetite, excessive sleeping)
0 celesteallen Tue, 26 Jan 2010 17:54:39 GMT view revision history
Up-regulation Heading: "Homeostatic regulation of altered synapses"

Loss of excitement at synapse

Number of postsynaptic receptors increased
0 celesteallen Tue, 26 Jan 2010 17:54:39 GMT view revision history
Down-regulation Heading: "Homeostatic regulation of altered synapses"

Repeated excitement of a synapse

Number of postsynaptic receptors reduced
0 celesteallen Tue, 26 Jan 2010 17:54:39 GMT view revision history
Synaptic Vesicles Containers that hold NT

Primed for release by arrival of AP
0 celesteallen Tue, 26 Jan 2010 17:48:34 GMT view revision history
Synaptic Cleft Another name for the Synaptic Gap

Space NT has to travel to travel in order to reach the subsequent nerve cell
0 celesteallen Tue, 26 Jan 2010 17:48:34 GMT view revision history
Axon Terminal Another name for terminal buttons 0 celesteallen Tue, 26 Jan 2010 17:48:34 GMT view revision history
Indirect Antagonist Blocks release of NT

Promotes reuptake of NT
0 celesteallen Tue, 26 Jan 2010 17:48:34 GMT view revision history
Indirect Agonist Artificailly reduces release of NT from presynaptic neuron without stimulation by AP

Blocks autoreceptor

Blocks reuptake of NT
-Ex: cocaine (dopamine)
0 celesteallen Tue, 26 Jan 2010 17:46:13 GMT view revision history
Antagonist Drug which inhibits the effect of the NT

-Occupies the receptor / receptor subtype
0 celesteallen Tue, 26 Jan 2010 17:46:13 GMT view revision history
Agonist Drug which mimics the effect of the NT

-Binds with receptor / receptor subtype
0 celesteallen Tue, 26 Jan 2010 17:46:13 GMT view revision history
Metabotropic NT binds to this kind of receptor

Second messenger is activated within neuron

-effects ion channels and genes
0 celesteallen Tue, 26 Jan 2010 17:46:13 GMT view revision history
Glutamate Example of an Ionotropic receptor that causes"

-Na+ channels open
-Depolarize membrane
0 celesteallen Tue, 26 Jan 2010 17:42:17 GMT view revision history
Ionotropic ("Classical neurotransmission") NT binds to this kind of receptor

Ion channels open / ions move in or out of cell

Membrane potential is excited / inhibited
0 celesteallen Tue, 26 Jan 2010 17:42:17 GMT view revision history
Metabolites Broken down components of NTs

-some are active
-quantitative measure of NT activity
0 celesteallen Tue, 26 Jan 2010 17:42:17 GMT view revision history
amt of Excitatory NT - amt of Inhibitory NT A second "equation" for the probability of action potential firing 0 celesteallen Tue, 26 Jan 2010 17:42:17 GMT view revision history
Strength of EPSP - Strength if IPSP One potential "equation" for the probability of action potential firing 0 celesteallen Tue, 26 Jan 2010 17:37:58 GMT view revision history
Temporal Summation The term used for when there is rapid stimulation of the same site on the postsynaptic neuron 0 celesteallen Tue, 26 Jan 2010 17:37:58 GMT view revision history
Spatial Summation The term used for when multiple sites of stimulation of the postsynaptic neuron 0 celesteallen Tue, 26 Jan 2010 17:37:58 GMT view revision history
Hyperpolarization The term for the negative change in voltage that occurs at the membrane during a synapse 0 celesteallen Tue, 26 Jan 2010 17:37:58 GMT view revision history
Inhibitorypostsynaptic potential (IPSP) The type of synapse where there is a negative change in voltage (hyperpoloarization) 0 celesteallen Tue, 26 Jan 2010 17:34:31 GMT view revision history
Depolarization This term refers to the electrical stimulation of the neuron causes a positive change in membrane potential 0 celesteallen Tue, 26 Jan 2010 17:34:31 GMT view revision history
Depolarization The term used when there is a positive change in voltage at the synapse 0 celesteallen Tue, 26 Jan 2010 17:34:31 GMT view revision history
Excitatory postsynaptic potential (EPSP) The type of synapse where there is a positive change in voltage (depoloarization) 0 celesteallen Tue, 26 Jan 2010 17:34:31 GMT view revision history
Plagues Areas of brain damage (in addition to lesions) caused by MS 0 celesteallen Thu, 21 Jan 2010 18:44:18 GMT view revision history
Tay-Sachs disease Type of disorder related to dysmelination

Progressive deterioration of motor and cognitive abilities, fatality by age 4

Genetic cause
0 celesteallen Thu, 21 Jan 2010 18:43:39 GMT view revision history
Guillain-Barre syndrome Type of disorder related to demyelination

Autoimmune disorder
0 celesteallen Thu, 21 Jan 2010 18:43:39 GMT view revision history
Guillain-Barre syndrome Type of disorder related to demyelination

Muscle weakness beginning in the legs and traveling upwards

Environmental causes
0 celesteallen Thu, 21 Jan 2010 18:43:39 GMT view revision history
Multiple Sclerosis Type of disorder related to demyelination

Progressive muscle weakness, motor impairment; difficulties with speech, vision, cognition

Genetic and environmental causes
0 celesteallen Thu, 21 Jan 2010 18:43:39 GMT view revision history
Myelinated axons Type of axons with directed flow of ions at Nodes of Ranvier facilitates transmission 0 celesteallen Thu, 21 Jan 2010 18:41:06 GMT view revision history
Myelinated axons Type of axons that operate at an enhanced speed

Prolonged electrical disturbance facilitates transmission

Faster transmission = potential for greater frequency
0 celesteallen Thu, 21 Jan 2010 18:41:06 GMT view revision history
Unmyelinated axons Type of axons that transmission depends on flow of ions throughout the entire axon 0 celesteallen Thu, 21 Jan 2010 18:41:06 GMT view revision history
Unmyelinated axons Type of axons that operate at a slower speed

Slower transmission limits the frequency of action potentials
0 celesteallen Thu, 21 Jan 2010 18:41:06 GMT view revision history
Saltatory Conduction The propagation of action potentials along myelinated axons from one node of Ranvier to the next node, increasing the conduction velocity of action potentials without needing to increase the diameter of an axon. 0 celesteallen Thu, 21 Jan 2010 18:37:48 GMT view revision history
Nodes of Ranvier Concentrated areas where ions can move across membrane 1 celesteallen Sat, 06 Feb 2010 20:12:09 GMT view revision history
Myelin Made by specialized glial cells

Speeds movement of action potentials alongthe axon
0 celesteallen Thu, 21 Jan 2010 18:37:48 GMT view revision history
Glial cells Cells that support neurons of CNS (oligodendrocytes) and PNS (Schwann cells)

-Maintain the nervous system

-Guide development of the NS

-Influence neuronal signaling
0 celesteallen Thu, 21 Jan 2010 18:37:48 GMT view revision history
Schwann Cells Cells that support neurons of the PNS

-Maintain nervous system

-Guide development of nervous system

-Influence neuronal signaling
0 celesteallen Thu, 21 Jan 2010 18:34:59 GMT view revision history
Oligodendrocytes Cells that support neurons of the CNS

-Maintain nervous system

-Guide development of nervous system

-Influence neuronal signaling
0 celesteallen Thu, 21 Jan 2010 18:34:59 GMT view revision history
Saturation The state of the neuron when it can't fire any more action potentials, even if you increase the stimulus 0 celesteallen Thu, 21 Jan 2010 18:34:59 GMT view revision history
Refractory Period This period of time prevents the action potential from moving backward 0 celesteallen Thu, 21 Jan 2010 18:34:59 GMT view revision history
Falling phase Phase of an action potential when:

Sodium channels shut, K+ channels open and allow it into neuron

Allows restoration of resting potential
0 celesteallen Thu, 21 Jan 2010 18:19:49 GMT view revision history
Peak Phase of an action potential when:

At highest membrane potential the cell will reach
0 celesteallen Thu, 21 Jan 2010 18:19:49 GMT view revision history
Rising phase Phase of an action potential when:

Depolarization, cell is stimulated
0 celesteallen Thu, 21 Jan 2010 18:19:49 GMT view revision history
Refractory period The time after the actino potential has fired at a specific location on the axon during which another action potential cannot fire at this location 0 celesteallen Thu, 21 Jan 2010 18:19:49 GMT view revision history
'Recovery' The state of a cell when NA+ channels close, K+ channels open and K+ leaves neuron

Resting potential is stabilized
0 celesteallen Thu, 21 Jan 2010 18:13:36 GMT view revision history
'Depolarization' The state of a cell when K+ enters neuron to reach threshold

Action potential fired
0 celesteallen Thu, 21 Jan 2010 18:13:36 GMT view revision history
'Stimulated' Heading: 'Summary of action potential' (4 main things, 1-7)

The state of a cell when the Na+ channels open and Na+ enters neuron

Membrane potential becomes less negative
1 celesteallen Sat, 06 Feb 2010 20:02:45 GMT view revision history
'At rest' The state of a cell when resting potential is maintained by sodium-potassium pump, concentration gradient & voltage 0 celesteallen Thu, 21 Jan 2010 18:13:36 GMT view revision history
Potassium channels What allows the membrane potential to move in a negative direction (until at rest)

Occurs when K+ moving out of cell
0 celesteallen Thu, 21 Jan 2010 18:11:03 GMT view revision history
Action Potential What occurs when a membrane potential reaches threshold 0 celesteallen Thu, 21 Jan 2010 18:11:03 GMT view revision history
Sodium channels The name of what the Na+ ions move into the cell through

(It does this when the neuron is stimulated, b/c membrane becomes more permeable to Na+)
0 celesteallen Thu, 21 Jan 2010 18:11:03 GMT view revision history
Depolarization Membrane potential becomes less negative and more positive due to the influx of Na+ ions that occurs when a neuron is stimulated 0 celesteallen Thu, 21 Jan 2010 18:11:03 GMT view revision history
Resting Potential Baseline level of cell's voltage that is -60mV to -70mV

Before the action potential
0 celesteallen Thu, 21 Jan 2010 18:01:05 GMT view revision history
Net force What is created by voltage, concentration gradient and the sodium-potassium pump that regulates the flow of ions 0 celesteallen Thu, 21 Jan 2010 18:01:04 GMT view revision history
Sodium Potassium Pump Brings K+ in and forcing Na+ out in order to maintain a proper membrane potential in the cell membrane 0 celesteallen Thu, 21 Jan 2010 18:01:04 GMT view revision history
Passive Word used to describe the movement of ions across the cell membrane

Related to the process of diffusion, voltage and concentration gradients of the cell membranes
0 celesteallen Thu, 21 Jan 2010 18:01:04 GMT view revision history
Concentration Gradient Difference in concentration of a substance between one area and another 0 celesteallen Thu, 21 Jan 2010 17:53:46 GMT view revision history
Pre-synaptic Cell The type of cell that releases neurotransmitter into the synapse 0 celesteallen Thu, 21 Jan 2010 17:53:46 GMT view revision history
Membrane Potential Voltage difference between the inside of the cell and the outside of the cell

Usually, -60mV to -70mV
0 celesteallen Thu, 21 Jan 2010 17:53:46 GMT view revision history
Voltage Difference in electrical potential arising from an imbalance of electrical charges between ions 0 celesteallen Thu, 21 Jan 2010 17:53:46 GMT view revision history
Extracellular fluid Type of cellular fluid mostly positive (in natural state) 0 celesteallen Thu, 21 Jan 2010 17:48:52 GMT view revision history
Intracellular fluid Type of cellular fluid mostly negative (in natural state) 0 celesteallen Thu, 21 Jan 2010 17:48:52 GMT view revision history
Semi-permeable Characteristic of the cell membrane

Allows some cells to travel through the cellular membrane but not others
0 celesteallen Thu, 21 Jan 2010 17:48:52 GMT view revision history
Ions Electrically active atoms

Ex: Na+, K+, Cl-
0 celesteallen Thu, 21 Jan 2010 17:48:52 GMT view revision history
Heirarchical control in Global control of ANS

Regulatory info comes from top, down
0 celesteallen Tue, 19 Jan 2010 18:33:02 GMT view revision history
Global control of ANS Coordinates needs of body with activity of ANS

controlled by command neurons in brain
0 celesteallen Tue, 19 Jan 2010 18:33:02 GMT view revision history
Local Feedback Local control of ANS

-sensory neurons near ANS target organ project info to CNS

-CNS conveys info about regulating ANS target

-involves only proximal neurons
0 celesteallen Tue, 19 Jan 2010 18:33:02 GMT view revision history
Efferent neurons project FROM CNS Type of neurons in vagus nerve

Stimulation of hunger cues
0 celesteallen Tue, 19 Jan 2010 18:30:13 GMT view revision history
Vagus nerve The nerve with efferent neurons that project FROM CNS 0 celesteallen Tue, 19 Jan 2010 18:30:13 GMT view revision history
Afferent neurons project TO CNS Type of neurons in vagus nerve

Low availability of energy for peripheral organ
0 celesteallen Tue, 19 Jan 2010 18:30:13 GMT view revision history
Vagus nerve The nerve with afferent neurons that project to the CNS 0 celesteallen Tue, 19 Jan 2010 18:30:13 GMT view revision history
Sympathetic nerve Type of nerve also known as postganglionic fibres 0 celesteallen Tue, 19 Jan 2010 18:27:05 GMT view revision history
Neurons (effectors) type of neurons under ANS control

smooth muscles
-synapses between neurons and muscles

secretion of hormones from glands
0 celesteallen Tue, 19 Jan 2010 18:27:05 GMT view revision history
Acetylcholine (ACh) Neurotransmitter that slows heartbeat

Very common in ANS
0 celesteallen Tue, 19 Jan 2010 18:27:05 GMT view revision history
Parasympathetic Branch Branch of ANS active while body is at rest

Ex: facilitates energy storage

Ex: slows heartbeat

Ex: aids digestion

Ex: facilitates activity of liver, bladder and kidneys

Ex: contracts pupils
0 celesteallen Tue, 19 Jan 2010 18:27:05 GMT view revision history
Sympathetic Branch Branch of the ANS that readies the body for action: FIGHT or FLIGHT

Ex: releases energy

Ex: releases epinephrine and norepinephrine

Ex: increases heartbeat

Ex: dilates pupils

Ex: inhibit digestion

Ex: inhibit activity of liver, kidneys and bladder
0 celesteallen Tue, 19 Jan 2010 18:19:45 GMT view revision history
Automatic Nervous System (ANS) Part of the nervous system that controls internal environment

Involuntary, controlled by smooth muscle
0 celesteallen Tue, 19 Jan 2010 18:19:45 GMT view revision history
Corticosteroids Prepare body for action

ACTH induces the release of this
0 celesteallen Tue, 19 Jan 2010 18:19:44 GMT view revision history
ACTH travels in bloodstream to adrenal gland, inducing release of corticosteroids 0 celesteallen Tue, 19 Jan 2010 18:19:44 GMT view revision history
CRF receptors Induce release of adrenocorticotrophic hormone (ACTH) from pituitary gland 0 celesteallen Tue, 19 Jan 2010 18:14:47 GMT view revision history
HPA Axis Includes the Hypothalamus, pituitary, and adrenal glands

Primary circuit activated by stressors
0 celesteallen Tue, 19 Jan 2010 18:14:47 GMT view revision history
Corticotropin-releasing factor (CRH or CRF) Neurohormone

Binds to CRF Receptors

"Stress" hormone
0 celesteallen Tue, 19 Jan 2010 18:14:47 GMT view revision history
Corticotropin-releasing factor (CRH or CRF) Neurohormone

Hypothalamus--> local blood vessel --> Pituitary gland
0 celesteallen Tue, 19 Jan 2010 18:14:47 GMT view revision history
Testosterone Classical hormone

Regulates sexual and aggressive behaviors
0 celesteallen Tue, 19 Jan 2010 18:11:32 GMT view revision history
Testosterone Classical hormone

Males: testes

Females: adrenal gland
0 celesteallen Tue, 19 Jan 2010 18:11:32 GMT view revision history
Oestrogen Classical hormone

Regulates sexual motivation in females
--increases responsibity to mate/fertility
0 celesteallen Tue, 19 Jan 2010 18:11:32 GMT view revision history
Arginine Vasopressin (AVP) Regulates body fluids
--slows the production of urine

Release is sensitive to water deficiency
--inhibits water loss
0 celesteallen Tue, 19 Jan 2010 18:09:02 GMT view revision history
Arginine Vasopressin (AVP) Hypothalamus --> pituitary -->bloodstream --> kidney (specific target organ) 0 celesteallen Tue, 19 Jan 2010 18:09:02 GMT view revision history
Insulin Regulates glucose levels

Pancreas --> bloodstream --> body

Release is sensitive to amount of glucose in the bloodstream AND environmental cues
0 celesteallen Tue, 19 Jan 2010 18:09:02 GMT view revision history
Adrenal glands Responsible for secreting cortisol (related to stress) 0 celesteallen Tue, 19 Jan 2010 18:09:02 GMT view revision history
Pancreas Secretes insulin (responsible for regulating glucose levels) 0 celesteallen Tue, 19 Jan 2010 18:05:47 GMT view revision history
Pineal gland Secretes hormone melatonin (activated by sunlight) 0 celesteallen Tue, 19 Jan 2010 18:05:47 GMT view revision history
Pituitary gland Responsible for secreting ACTH, oxytocin and AVP 0 celesteallen Tue, 19 Jan 2010 18:05:47 GMT view revision history
Neurohormone Hormones in brain that are secreted by a group of neurons with local targets

Can bind with receptors and exert effects on target cells
0 celesteallen Tue, 19 Jan 2010 18:05:47 GMT view revision history
Hormones Chemicals that act throughout the body and are secreted by glands with global targets 0 celesteallen Tue, 19 Jan 2010 18:03:43 GMT view revision history
Cranial Nerves Spread information from the brain to teh rest of the head

Ex: facial nerves, control jaw, throat, eyes, olfactory
0 celesteallen Tue, 19 Jan 2010 18:03:43 GMT view revision history
Dendritic Spines Enhance the surface area of the dendrite and allow more synapses to be possible with a neuron

Show plasticity, increase neurotransmission communication
0 celesteallen Tue, 19 Jan 2010 18:03:43 GMT view revision history
Dendrodendritic Synapse A type of synapse in which a dendrite of one neuron comes in contact with a dendrite of another neuron 0 celesteallen Tue, 19 Jan 2010 18:03:43 GMT view revision history
Axon with only a cell body Transmits information using smooth changes in voltage 0 celesteallen Tue, 19 Jan 2010 17:57:51 GMT view revision history
Sensory Neurons Den--Axon--Cell body--Axon--Den

Type of neuron that can convey information over large distances

Can have synapses at dendrites, axon or cell body
0 celesteallen Tue, 19 Jan 2010 17:57:51 GMT view revision history
Postsynaptic Neuron what a neuron is called when it is NOT sending a message to another neuron 0 celesteallen Tue, 19 Jan 2010 17:57:51 GMT view revision history
Presynaptic Neuron what a neuron is called when it is sending a message to another neuron 0 celesteallen Tue, 19 Jan 2010 17:57:51 GMT view revision history
Dendrites The part of the neuron that (for the most part) receives the messages from other neurons 0 celesteallen Tue, 19 Jan 2010 17:53:27 GMT view revision history
Soma Cell body of neuron, contains DNA 0 celesteallen Tue, 19 Jan 2010 17:53:27 GMT view revision history
Axoaxonic Synapse a synapse in which the axon of one neuron comes in contact with the axon of another neuron 0 celesteallen Tue, 19 Jan 2010 17:53:27 GMT view revision history
Axosomatic Synapse a synapse in which the axon of one neuron comes in contact with the cell body of another neuron. 0 celesteallen Tue, 19 Jan 2010 17:53:27 GMT view revision history
Axodendretic Synapse a synapse in which the axon of one neuron comes in contact with the dendrites of another neuron. 0 celesteallen Tue, 19 Jan 2010 17:51:31 GMT view revision history
Terminal Button Exist at the ends of the many branches that divide out from the axon

They receive the message transferred down the axon, store them in their synaptic vesicles and are responsible for then secreting these transmitter substances.
0 celesteallen Tue, 19 Jan 2010 17:51:31 GMT view revision history
Spinal cord First point of contact, connections between PNS and CNS 0 celesteallen Tue, 19 Jan 2010 17:51:31 GMT view revision history
Neuroplasticity / Brain plasticity This term refers to the brain’s ability to CHANGE throughout life. The brain has the amazing ability to reorganize itself by forming new connections between brain cells (neurons). 0 celesteallen Tue, 19 Jan 2010 17:51:31 GMT view revision history
Myelin Sheath Insulates the axon of a neuron and allows for faster neural firings 0 celesteallen Tue, 19 Jan 2010 17:40:57 GMT view revision history
Axon Long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma. 0 celesteallen Tue, 19 Jan 2010 17:40:57 GMT view revision history
Efferent Neuron Neurons that travel away from the brain /away from a specific brain region

Ex: motor neuron
0 celesteallen Tue, 19 Jan 2010 17:40:57 GMT view revision history
Afferent Neurons Neurons that travel towards the brain / to a specific brain region

Ex: sensory neuron
0 celesteallen Tue, 19 Jan 2010 17:40:57 GMT view revision history
Tract / pathway in CNS

bundle of axons
0 celesteallen Tue, 19 Jan 2010 17:33:58 GMT view revision history
Nerve in PNS

bundle of axons
0 celesteallen Tue, 19 Jan 2010 17:33:58 GMT view revision history
Ganglion in PNS

group of cell bodies of neurons
0 celesteallen Tue, 19 Jan 2010 17:33:58 GMT view revision history
Dermatone (spinal cord)

sensory surface of the body
0 celesteallen Tue, 19 Jan 2010 17:33:58 GMT view revision history
Gray matter (spinal cord)

cell bodies
0 celesteallen Tue, 19 Jan 2010 17:32:18 GMT view revision history
Spinal Nerve (spinal cord)

dorsal and ventral root
0 celesteallen Tue, 19 Jan 2010 17:32:18 GMT view revision history
Ventral Root (spinal cord)

motor neuron axons
0 celesteallen Tue, 19 Jan 2010 17:32:18 GMT view revision history
DRG (spinal cord)

sensory neuron cell bodies
0 celesteallen Tue, 19 Jan 2010 17:32:18 GMT view revision history
Hormones Chemicals that act throughout the body and are secreted by glands

- Adrenal gland --> cortisol
0 celesteallen Tue, 19 Jan 2010 02:16:55 GMT view revision history
How are neuromodulators unlike NTs -Travel to receptors farther away
-Exert 'global' effects
-Modulate activity of the postsynaptic neuron (has a range of effects)
-Can influence the release of NTs (facilitate or inhibit)
-Can influence the ability of the NT to bind to the postsynaptic receptor (facilitate or inhibit)
0 celesteallen Tue, 19 Jan 2010 02:16:10 GMT view revision history
How are neuromodulators similar to NT -Are released from neurons
-Have effects at neighboring neurons
-Bind to receptors
0 celesteallen Tue, 19 Jan 2010 02:16:10 GMT view revision history
Neuromodulator Like NTs
-Are released from neurons
-Have effects at neighboring neurons
-Bind to receptors

Unlike NTs
-Travel to receptors farther away
-Exert 'global' effects
-Modulate activity of the postsynaptic neuron (has a range of effects)
-Can influence the release of NTs (facilitate or inhibit)
-Can influence the ability of the NT to bind to the postsynaptic receptor (facilitate or inhibit)
0 celesteallen Tue, 19 Jan 2010 02:16:10 GMT view revision history
GABA Classical neurotransmitter

Primary inhibitory NT
0 celesteallen Tue, 19 Jan 2010 02:16:10 GMT view revision history
Glutamate Classical neurotransmitter

Primary excitatory NT
0 celesteallen Tue, 19 Jan 2010 02:12:24 GMT view revision history
Inhibitory Synapse Neurons 1 & 2 release neurotransmitter into their synapses with neuron 4

Since the synapse with neuron 2 is inhibitory, the input from this synapse opposes the input from the synapse with neuron 1

The net effect of inhibition cancels out the net effect of excitation

Neuron 4 is not stimulated
0 celesteallen Tue, 19 Jan 2010 02:12:24 GMT view revision history
More Excitatory Synapses Neurons 1 & 3 release neurotransmitter into their synapses with neuron 4

With the addition of excitatory input from neuron 3, neuron 4 is stimulated to a greater extent

Action potentials fire in neuron 4 with a greater frequency
0 celesteallen Tue, 19 Jan 2010 02:12:24 GMT view revision history
Excitatory Synapses Action potentials arrive at neuron 1

Neurotransmitter is released at the synapse between neuron 1 & 4

Neuron 4 is stimulated, action potentials fire
0 celesteallen Tue, 19 Jan 2010 02:12:24 GMT view revision history
Inhibitory Synapses Types of synapses

Between 2 & 4
0 celesteallen Tue, 19 Jan 2010 02:03:44 GMT view revision history
Excitatory Synapses Types of synapses

Between 1 & 4 and between 3 & 4
0 celesteallen Tue, 19 Jan 2010 02:03:44 GMT view revision history
Circuit Types of synapses

Neurons 1-4 creates this
0 celesteallen Tue, 19 Jan 2010 02:03:44 GMT view revision history
Synapse (Action Potential)

Structure that permits a neuron to pass an electrical or chemical signal to another cell
0 celesteallen Tue, 19 Jan 2010 02:03:44 GMT view revision history
Neurotransmitter (Action Potential)

Upon reaching threshold, this is released into the synapse
0 celesteallen Tue, 19 Jan 2010 02:00:46 GMT view revision history
Threshold (Action Potential)

After a series of action potentials, the neuron may reach this...
0 celesteallen Tue, 19 Jan 2010 02:00:46 GMT view revision history
Action Potentials Information is encoded as the frequency of the electrical signals

Information arises from: which neurons are active and the frequency of action potentials in those neurons
0 celesteallen Tue, 19 Jan 2010 02:00:46 GMT view revision history
Autonomic Nervous System Pat of the CNS that is involuntary

-Internal world (smooth muscles)
0 celesteallen Tue, 19 Jan 2010 02:00:46 GMT view revision history
Somatic Nervous System Part of the CNS that contains the Voluntary and Involuntary 0 celesteallen Tue, 19 Jan 2010 01:53:39 GMT view revision history
Depression Mood disorder characterized by negative affect, disturbances in appetite / sleep, fatigue, lack of motivation

Reactive: in response to external events

Non-reactive: appears spontaneously (may be due to internal alterations in neurochemistry)

Multidimensional, complex causes

Genetic
Environmental/ Learning

Evolutionary context?
0 celesteallen Tue, 19 Jan 2010 01:53:39 GMT view revision history
Specialization of cells in the body All cells contain all DNA but only certain segments of the DNA are used in a given cell to express a given protein 0 celesteallen Tue, 19 Jan 2010 01:53:39 GMT view revision history
Genes Sections of DNA

Located on paired chromosomes

A gene pair determines a trait

Allele variant of a given gene
0 celesteallen Tue, 19 Jan 2010 01:53:39 GMT view revision history
Selective Breeding The process of breeding plants and animals for particular genetic traits 0 celesteallen Tue, 19 Jan 2010 01:26:36 GMT view revision history
Strains Subdivisions of a species that displays its own specific phenotypes, which are correlated with different genotypes 0 celesteallen Tue, 19 Jan 2010 01:26:36 GMT view revision history
Species-typical behavior Behavior commonly displayed by most members of a species

Displayed in 'normal' environment

Triggered by specific environmental stimuli

Ex: speech
0 celesteallen Tue, 19 Jan 2010 01:26:36 GMT view revision history
Innate / Instinctive behaviors Behaviors that are
1) Genetically determined

2) Make evolutionary sense
0 celesteallen Tue, 19 Jan 2010 01:23:38 GMT view revision history
Heritability Degree to which differences in a trait are due to differences in genetics 0 celesteallen Tue, 19 Jan 2010 01:23:38 GMT view revision history
Down's Syndrome Genetic / inherited disorder

AKA: trisomy 21

Results from inheritance of an extra 21st chromosome and is characterized by cognitive disabilities and physical abnormalities
0 celesteallen Tue, 19 Jan 2010 01:23:38 GMT view revision history
Huntington's Disease Genetic / inherited disorder

The parent carrying the dominant gene for this disorder will also have it

Manifests itself later in life
1 celesteallen Mon, 08 Feb 2010 00:13:15 GMT view revision history
Huntington's Disease Genetic / inherited disorder

Results from the presence of one dominant allele, and is characterized by abnormal body movements, changes in personality and memory impairments

-If 1 parent has it, 30% chance
0 celesteallen Tue, 19 Jan 2010 01:20:19 GMT view revision history
Phenylalnine Protein that if not produced properly (caused by genetic mutation) causes PKU

-If parents both have it, offspring 21% chance
0 celesteallen Tue, 19 Jan 2010 01:20:19 GMT view revision history
PKU Genetic/inherited disorder

Results from a genetic mutation that causes inability to properly process the protein, phenylalnine
0 celesteallen Tue, 19 Jan 2010 01:20:19 GMT view revision history
Mutations The phenotype that results when genes are altered during reproduction 0 celesteallen Tue, 19 Jan 2010 01:20:19 GMT view revision history
Phenotype Physical characteristic of an individual

Result of genotype + environment
0 celesteallen Tue, 19 Jan 2010 01:15:57 GMT view revision history
Genotype Collection of all genes of an individual 0 celesteallen Tue, 19 Jan 2010 01:15:57 GMT view revision history
Protein synthesis -Transcription of DNA to mRNA

-Translation of mRNA to protein
0 celesteallen Tue, 19 Jan 2010 01:15:57 GMT view revision history
Motivation Internally drives behavior by appropriately directing action and attention based on the environment 0 celesteallen Tue, 19 Jan 2010 01:15:57 GMT view revision history
Action Voluntary, conscious response to stimuli

-Open-ended
0 celesteallen Tue, 19 Jan 2010 01:12:02 GMT view revision history
Reflex Automatic response to stimuli

-Stereotyped
0 celesteallen Tue, 19 Jan 2010 01:12:02 GMT view revision history
Natural Selection Process that acts on individuals, as their genes are selected to be passed on 0 celesteallen Tue, 19 Jan 2010 01:12:02 GMT view revision history
Evolution Process that occurs on a large timescale within a species, over many generations of natural selection 0 celesteallen Tue, 19 Jan 2010 01:12:02 GMT view revision history
Adaptation The suitability of a trait for an environment

-A sum of adapted traits (vs non-adapted traits) directly influences an individual's fitness
0 celesteallen Tue, 19 Jan 2010 01:10:15 GMT view revision history
Fitness Measure of the ability of an animal to pass on its genes 0 celesteallen Tue, 19 Jan 2010 01:10:15 GMT view revision history
Trait characteristic (genes which encode physical features/ or result in behaviors)

-Adaptations

-Functional parts of natural selection
2 celesteallen Tue, 09 Feb 2010 00:33:09 GMT view revision history
Function Reproductive success / success in passing along genes 0 celesteallen Tue, 19 Jan 2010 01:10:15 GMT view revision history
Natural Selection The process by which specific genes are favored within a given environment to produce viable offspring (pass along the genes) 0 celesteallen Tue, 19 Jan 2010 01:08:00 GMT view revision history
Evolution Change occurring in a species across generations due to genetic variation 0 celesteallen Tue, 19 Jan 2010 01:08:00 GMT view revision history
Monism The mind and the brain are two ways to refer to the same entity, a biological structure that is part of the body

Thus, conscious thought arises from biological functions
0 celesteallen Tue, 19 Jan 2010 01:08:00 GMT view revision history
Dualism The mind is viewed as a separate entity from the brain and the body

Mind = conscious thought, Brain = biological structure
0 celesteallen Tue, 19 Jan 2010 01:07:59 GMT view revision history
Morris Water Maze Experiment A behavioral procedure designed to test spatial memory that is tested on rats 0 celesteallen Tue, 19 Jan 2010 01:04:28 GMT view revision history
Homeostasis (no action?) Homeostatic set point, ex: optimal amt of blood sugar is in the system

Environmental disturbance, ex: 5 mile run

Mechanisms to restore homeostasis balance, ex: Drop in blood sugar recognized by the PNS, sends signals to CNS... CNS sends hunger signals, so you eat...

Homeostatic set point restored, so negative feedback signals mechanisms to inaction
0 celesteallen Tue, 19 Jan 2010 01:04:28 GMT view revision history
Homeostasis (no action) Homeostatic set point

Environmental disturbance

mechanisms to restore homeostasis balance

Homeostatic set point is restored, and NEGATIVE FEEDBACK is signals mechanisms to inaction
0 celesteallen Tue, 19 Jan 2010 01:04:28 GMT view revision history
Homeostasis Environmental stimuli are sensed by neurons of PNS

Neurons of PNS send sensory information to neurons of the CNS

Neurons of the CNS process the information and send the feedback about the behavioral output to the PNS

Behavior is performed
0 celesteallen Tue, 19 Jan 2010 01:04:28 GMT view revision history
Homeostatic Set point The body's optimal state 0 celesteallen Tue, 19 Jan 2010 00:54:25 GMT view revision history
Behavior The actions or reactions of an object or organism, usually in relation to the environment

They can be conscious or subconscious, overt or covert, and voluntary or involuntary.
0 celesteallen Tue, 19 Jan 2010 00:54:25 GMT view revision history
4 Perspectives used to understand biological psychology 1. causal

2. developmental/learning

3. evolutionary

4. functional
0 celesteallen Tue, 19 Jan 2010 00:54:25 GMT view revision history
Biological Psychology Interactions between the environment (internal or external) and the brain result in behavior 0 celesteallen Tue, 19 Jan 2010 00:54:25 GMT view revision history

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